| http://purl.uniprot.org/citations/17135600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17135600 | http://www.w3.org/2000/01/rdf-schema#comment | "The adenosine triphosphate-binding cassette A1 (ABCA1) gene plays a key role in reverse cholesterol transport. Some ABCA1 gene polymorphisms have been associated with high-density lipoprotein-cholesterol (HDL-C) concentrations. The aim of this study was to assess the effect of three polymorphisms, C69T, G378C, and G1051A (R219K), on HDL-C levels and their interaction with BMI in more than 5000 French whites from the D.E.S.I.R. (Data from an Epidemiological Study on the Insulin Resistance syndrome) cohort study. The T allele of the C69T single nucleotide polymorphism (SNP) was associated with higher HDL-C levels in normal-weight men (BMI <25 kg/m(2)). The C allele of the G378C SNP was associated with lower HDL-C in overweight subjects (BMI > or =25 kg/m(2)). For the G1051A SNP, in the normal-weight group, the minor A allele was significantly associated with higher HDL-C levels. In contrast, in overweight people, the minor allele was associated with lower HDL-C levels. After accounting for multiple testing, empiric p values remained significant for the associations between G378C SNP and HDL-C in the overweight group and between G1051A SNP and HDL-C in the normal-weight group. This study suggests that ABCA1 gene polymorphisms modulate HDL-C concentrations, in interaction with BMI, and, thus, they might influence cardiovascular risk in the general population."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.org/dc/terms/identifier | "doi:10.1038/oby.2006.217"xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Fumeron F."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Balkau B."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Marre M."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Tichet J."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Royer B."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Pean F."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Chesnier M.C."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Bellili N."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Porchay I."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Caradec A."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/author | "Cogneau J."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/name | "Obesity (Silver Spring)"xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/pages | "1874-1879"xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/title | "ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study."xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/17135600 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17135600 |
| http://purl.uniprot.org/citations/17135600 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17135600 |
| http://purl.uniprot.org/uniprot/#_B7XCW9-mappedCitation-17135600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17135600 |
| http://purl.uniprot.org/uniprot/#_B2RUU2-mappedCitation-17135600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17135600 |
| http://purl.uniprot.org/uniprot/#_B1AMI2-mappedCitation-17135600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17135600 |
| http://purl.uniprot.org/uniprot/#_O95477-mappedCitation-17135600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17135600 |