| http://purl.uniprot.org/citations/17137799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17137799 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify interleukin-10 (IL-10)-producing cells in vivo, we generated a knockin mouse where an internal ribosome entry site (IRES) green fluorescence protein (GFP) element was inserted immediately before the polyadenylation site of the IL-10 gene. GFP fluorescence in cells from these mice was found to correlate positively with IL-10 protein expression. With this model, we found that after multiple T cell receptor (TCR) stimulations, strong expression of IL-10 was produced specifically by intraepithelial lymphocytes (IEL) in the small intestine and colonic lamina propria lymphocytes (cLPL). We found that anti-CD3 treatment induces T regulatory cell 1 (Tr1)-like cells in small intestinal IEL (sIEL) and led to the accumulation of naturally occurring regulatory T (nTreg) cells in colonic LPL (cLPL). These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.09.013"xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Wan Y.Y."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Galan J.E."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Kim S.T."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Sutterwala F.S."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Lara-Tejero M."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Kamanaka M."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/author | "Harhaj E."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/pages | "941-952"xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/title | "Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse."xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/17137799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17137799 |
| http://purl.uniprot.org/citations/17137799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17137799 |
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