| http://purl.uniprot.org/citations/17139249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17139249 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule arrays direct intracellular organization and define cellular polarity. Here, we show a novel function of glycogen synthase kinase-3beta (GSK-3beta) in the organization of microtubule arrays through the interaction with Bicaudal-D (BICD). BICD is known to form a complex with dynein-dynactin and to function in the intracellular vesicle trafficking. Our data revealed that GSK-3beta is required for the binding of BICD to dynein but not to dynactin. Knockdown of GSK-3beta or BICD reduced centrosomally focused microtubules and induced the mislocalization of centrosomal proteins. The unfocused microtubules in GSK-3beta knockdown cells were rescued by the expression of the dynein intermediate chain-BICD fusion protein. Microtubule regrowth assays showed that GSK-3beta and BICD are required for the anchoring of microtubules to the centrosome. These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization."xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601459"xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/author | "Hoogenraad C.C."xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/author | "Fumoto K."xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/pages | "5670-5682"xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/title | "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome."xsd:string |
| http://purl.uniprot.org/citations/17139249 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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