http://purl.uniprot.org/citations/17141398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17141398 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveThe plasminogen activator system and beta-hCG may affect neural crest cells and angiogenesis, and thereby embryogenesis. Therefore, we investigated these parameters in amniotic fluids of pregnancies with a complex congenital malformation.Study designIn a case-control study amniotic fluid samples were collected from 62 pregnancies with a complex congenital malformation and from 110 healthy control pregnancies at an obstetric department of a large university hospital in the Netherlands. We determined concentrations of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitors (PAI-1, PAI-2), tPA approximately PAI-1 and uPA approximately PAI-1 complexes, and beta-hCG with enzyme-linked immunosorbent assays. Mann-Whitney U-tests and analysis of covariance, adjusting for gestational and maternal age, were performed for data comparisons.ResultsCompared with controls, cases demonstrated significantly lower adjusted geometric mean levels of uPA (24%), tPA (> or =19%) and tPA approximately PAI-1 (35%). Cases showed significantly higher adjusted mean levels of beta-hCG (> or =48%) and PAI-2 (10 ng/mL) than controls. Mean PAI-1 and uPA approximately PAI-1 levels were comparable between both groups.ConclusionsDisturbances in the plasminogen activator system and beta-hCG levels are suggested to be involved in the pathogenesis of complex congenital malformations by affecting neural crest cell migration and angiogenesis."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejogrb.2006.10.033"xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Sweep F.C."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Geurts-Moespot A."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Hop W.C."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Steegers E.A."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Steegers-Theunissen R.P."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Ursem N.T."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/author | "Verkleij-Hagoort A.C."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/name | "Eur J Obstet Gynecol Reprod Biol"xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/pages | "47-52"xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/title | "Complex congenital malformations and the impact of the plasminogen activator system and beta-hCG in amniotic fluid."xsd:string |
http://purl.uniprot.org/citations/17141398 | http://purl.uniprot.org/core/volume | "135"xsd:string |
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