| http://purl.uniprot.org/citations/17142463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17142463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17142463 | http://www.w3.org/2000/01/rdf-schema#comment | "The PHD finger motif is a signature chromatin-associated motif that is found throughout eukaryotic proteomes. Here we have determined the histone methyl-lysine binding activity of the PHD fingers present within the Saccharomyces cerevisiae proteome. We provide evidence on the genomic scale that PHD fingers constitute a general class of effector modules for histone H3 trimethylated at lysine 4 (H3K4me3) and histone H3 trimethylated at lysine 36 (H3K36me3). Structural modeling of PHD fingers demonstrates a conserved mechanism for recognizing the trimethyl moiety and provides insight into the molecular basis of affinity for the different methyl-histone ligands. Together, our study suggests that a common function for PHD fingers is to transduce methyl-lysine events and sheds light on how a single histone modification can be linked to multiple biological outcomes."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c600286200"xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c600286200"xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Bedford M.T."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Bedford M.T."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Gozani O."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Gozani O."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Davrazou F."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Davrazou F."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Kutateladze T.G."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Kutateladze T.G."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Briggs S.D."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Briggs S.D."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Chan S.M."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Chan S.M."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Fingerman I.M."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Fingerman I.M."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Howe L."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Howe L."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Kachirskaia I."xsd:string |
| http://purl.uniprot.org/citations/17142463 | http://purl.uniprot.org/core/author | "Kachirskaia I."xsd:string |