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| http://purl.uniprot.org/citations/17142760 | http://www.w3.org/2000/01/rdf-schema#comment | "IFNs regulate most MHC class I genes by stimulating transcription initiation. As shown previously, IFN-gamma controls HLA-A expression primarily at the posttranscriptional level. We have defined two 8-base sequences in a 39-nucleotide region in the 3'-transcribed region of the HLA-A gene that are required for the posttranscriptional response to IFN-gamma. Stimulation of HLA-A expression by IFN-gamma requires nuclear export of HLA-A mRNA by chromosome maintenance region 1 (CRM-1). Treatment of cells with leptomycin B, a specific inhibitor of CRM-1, completely inhibited IFN-gamma induction of HLA-A. Expression of a truncated, dominant-negative form of the nucleoporin NUP214/CAN, DeltaCAN, that specifically interacts with CRM-1, also prevented IFN-gamma stimulation of HLA-A, providing confirmation of the role of CRM-1. Increased expression of HLA-A induced by IFN-gamma also requires protein methylation, as shown by the fact that treatment of SK-N-MC cells or HeLa cells with the PRMT1 inhibitor 5'-methyl-5'-thioadenosine abolished the cellular response to IFN-gamma. In contrast with HLA-A, IFN-gamma-induced expression of the HLA class Ib gene, HLA-E, was not affected by either 5'-methyl-5'-thioadenosine or leptomycin B. These results provide proof of principle that it is possible to differentially modulate the IFN-gamma-induced expression of the HLA-E and HLA-A genes, whose products often mediate opposing effects on cellular immunity to tumor cells, pathogens, and autoantigens."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.12.8612"xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/author | "Ginder G.D."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/author | "Roesser J.R."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/author | "Browne S.K."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/author | "Zhu S.Z."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/pages | "8612-8619"xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/title | "Differential IFN-gamma stimulation of HLA-A gene expression through CRM-1-dependent nuclear RNA export."xsd:string |
| http://purl.uniprot.org/citations/17142760 | http://purl.uniprot.org/core/volume | "177"xsd:string |
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