| http://purl.uniprot.org/citations/17145718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17145718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17145718 | http://www.w3.org/2000/01/rdf-schema#comment | "The Brn-3a and Brn-3b transcription factor have opposite and antagonistic effects in neuroblastoma cells since Brn-3a is associated with differentiation whilst Brn-3b enhances proliferation in these cells. In this study, we demonstrate that like Brn-3a, Brn-3b physically interacts with p53. However, whereas Brn-3a repressed p53 mediated Bax expression but cooperated with p53 to increase p21cip1/waf1, this study demonstrated that co-expression of Brn-3b with p53 increases trans-activation of Bax promoter but not p21cip1/waf1. Consequently co-expression of Brn-3b with p53 resulted in enhanced apoptosis, which is in contrast to the increased survival and differentiation, when Brn-3a is co-expressed with p53. For Brn-3b to cooperate with p53 on the Bax promoter, it requires binding sites that flank p53 sites on this promoter. Furthermore, neurons from Brn-3b knock-out (KO) mice were resistant to apoptosis and this correlated with reduced Bax expression upon induction of p53 in neurons lacking Brn-3b compared with controls. Thus, the ability of Brn-3b to interact with p53 and modulate Bax expression may demonstrate an important mechanism that helps to determine the fate of cells when p53 is induced."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkl878"xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkl878"xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Latchman D.S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Latchman D.S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Bowen S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Bowen S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Morris P.J."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Morris P.J."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Perez-Sanchez C."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Perez-Sanchez C."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Budhram-Mahadeo V.S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Budhram-Mahadeo V.S."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Ensor E."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/author | "Ensor E."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/pages | "6640-6652"xsd:string |
| http://purl.uniprot.org/citations/17145718 | http://purl.uniprot.org/core/pages | "6640-6652"xsd:string |