| http://purl.uniprot.org/citations/17145954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17145954 | http://www.w3.org/2000/01/rdf-schema#comment | "The G534E polymorphism (Marburg I [MI]) of factor VII-activating protease (FSAP) is associated with carotid stenosis and cardiovascular disease. We have previously demonstrated that FSAP is present in atherosclerotic plaques and it is a potent inhibitor of vascular smooth muscle proliferation and migration in vitro. The effect of wild-type (WT)- and MI-FSAP on neointima formation in the mouse femoral artery after wire-induced injury was investigated. Local application of WT-FSAP led to a 70% reduction in the neointima formation, and this effect was dependent on the protease activity of FSAP. MI-FSAP did not inhibit neointima formation in vivo. This is due to a reduced proteolytic activity of MI-FSAP, compared to WT-FSAP, toward platelet-derived growth factor BB, a key mediator of neointima development. The inability of MI-FSAP to inhibit vascular smooth muscle accumulation explains the observed linkage between the MI-polymorphism and increased cardiovascular risk. Hence, FSAP has a protective function in the vasculature, and analysis of MI polymorphism is likely to be clinically relevant in restenosis."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20052546"xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Daniel J.M."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Preissner K.T."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Weimer T."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Kanse S.M."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Braun-Dullaeus R.C."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Tillmanns H."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Kemkes-Matthes B."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Hersemeyer K."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Sedding D."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Brunsch H."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/author | "Muhl L."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/pages | "2801-2807"xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/title | "The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation."xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/17145954 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17145954 |
| http://purl.uniprot.org/citations/17145954 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17145954 |
| http://purl.uniprot.org/uniprot/#_E9Q092-mappedCitation-17145954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145954 |
| http://purl.uniprot.org/uniprot/#_E9Q0C5-mappedCitation-17145954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145954 |
| http://purl.uniprot.org/uniprot/#_E9QM92-mappedCitation-17145954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145954 |
| http://purl.uniprot.org/uniprot/#_B7Z8Q5-mappedCitation-17145954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17145954 |