| http://purl.uniprot.org/citations/17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17148586 | http://www.w3.org/2000/01/rdf-schema#comment | "Several approaches to target insulin-like growth factor-1 (IGF-1) signaling have resulted in the inhibition of the growth of a broad range of tumor cells. Malignant T cells are insensitive to the antiproliferative effects of the interferon-gamma (IFN-gamma)/signal transducer and activator of transcription 1 (STAT1) pathway because of the IGF-1-dependent internalization of the IFN-gammaR2 signaling chain. Here we show that human malignant T cells are also resistant to the growth inhibitory effect of both the IGF-1 receptor-specific inhibitor picropodophyllin (PPP) and retrovirus-mediated gene transfer of a dominant negative IGF-1 receptor. However, blockade of IGF-1 receptor perturbs IFN-gammaR2 internalization and induces its cell surface accumulation in malignant T cells. This allows the reinstatement of the IFN-gamma-induced STAT1 activation, a high expression of proapoptotic molecules, and the suppression of malignant T-cell growth both in vitro and in vivo in a severe combined immunodeficiency (SCID) mouse model. These data indicate that the inhibition of IGF-1 signaling combined with IFN-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-07-034231"xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Chiarle R."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Conti L."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Longo A."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Novelli F."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Giovarelli M."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Bernabei P."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/author | "Regis G."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/pages | "2496-2504"xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/title | "In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth."xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17148586 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17148586 |
| http://purl.uniprot.org/citations/17148586 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17148586 |
| http://purl.uniprot.org/uniprot/#_A0A1U9WZ84-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_Q13429-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_Q14610-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_Q14611-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |
| http://purl.uniprot.org/uniprot/#_Q14612-mappedCitation-17148586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17148586 |