| http://purl.uniprot.org/citations/17148664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17148664 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth hormone (GH) regulates anabolic metabolism via activation of the STAT5b transcription factor and reduces mucosal inflammation in colitis. Peroxisome proliferator-activated receptor (PPAR) gamma suppresses mucosal inflammation and is regulated by GH through STAT5b. We hypothesized that the GH:STAT5b axis influences susceptibility to colitis via regulation of local PPARgamma abundance. Colon biopsies from children with newly diagnosed Crohn's disease (CD) and controls were exposed to GH in short-term organ culture. Trinitrobenzene sulfonic acid (TNBS) administration was used to induce colitis in STAT5b-deficient mice and wild-type controls, with and without rosiglitazone pretreatment. GH receptor, STAT5b, PPARgamma, and nuclear factor kappaB activation and expression were determined. Epithelial cell GH receptor expression and GH-dependent STAT5b activation and PPARgamma expression were reduced in CD colon. STAT5b-deficient mice exhibited reduced basal PPARgamma nuclear abundance and developed more severe proximal colitis after TNBS administration. This was associated with a significant increase in mucosal nuclear factor kappaB activation at baseline and after TNBS administration. Rosiglitazone ameliorated colitis in wild-type mice but not STAT5b-deficient mice. GH-dependent STAT5b activation is impaired in affected CD colon and contributes to chronic mucosal inflammation via down-regulation of local PPARgamma expression. Therapeutic activation of the GH:STAT5b axis therefore represents a novel target for restoring both normal anabolic metabolism and mucosal tolerance in CD."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2006.060186"xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Frank S.J."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Denson L.A."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Loesch K."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Benight N."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/author | "Osuntokun B."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/pages | "1999-2013"xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/title | "Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis."xsd:string |
| http://purl.uniprot.org/citations/17148664 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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