| http://purl.uniprot.org/citations/17156361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17156361 | http://www.w3.org/2000/01/rdf-schema#comment | "The rocker mice are hereditary ataxic mutants that carry a point mutation in the gene encoding the CaV2.1 (P/Q-type) Ca2+ channel alpha1 subunit, and show the mildest symptoms among the reported CaV2.1 mutant mice. We studied the basic characteristics of the rocker mutant Ca2+ channel and their impacts on excitatory synaptic transmission in cerebellar Purkinje cells (PCs). In acutely dissociated PC somas, the rocker mutant channel showed a moderate reduction in Ca2+ channel current density, whereas its kinetics and voltage dependency of gating remained nearly normal. Despite the small changes in channel function, synaptic transmission in the parallel fiber (PF)-PC synapses was severely impaired. The climbing fiber inputs onto PCs showed a moderate impairment but could elicit normal complex spikes. Presynaptic function of the PF-PC synapses, however, was unexpectedly almost normal in terms of paired-pulse facilitation, sensitivity to extracellular Ca2+ concentration and glutamate concentration in synaptic clefts. Electron microscopic analyses including freeze-fracture replica labeling revealed that both the number and density of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors substantially decreased without gross structural changes of the PF-PC synapses. We also observed an abnormal arborization of PC dendrites in young adult rocker mice (approximately 1 month old). These lines of evidence suggest that even a moderate dysfunction of CaV2.1 Ca2+ channel can cause substantial changes in postsynaptic molecular composition of the PF-PC synapses and dendritic structure of PCs."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2006.05191.x"xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Kodama T."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Mori Y."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Molnar E."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Imoto K."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Miyata M."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Wakamori M."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Fukazawa Y."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Shigemoto R."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/author | "Itsukaichi-Nishida Y."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/pages | "2993-3007"xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/title | "A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses."xsd:string |
| http://purl.uniprot.org/citations/17156361 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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