| http://purl.uniprot.org/citations/17156375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17156375 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha-synuclein (alpha-Syn) has been studied in the context of Parkinson's disease, but its normative role remains elusive. We have shown that alpha-Syn regulates the homeostasis of dopaminergic and serotonergic synapses, through trafficking of the dopamine and serotonin transporter, respectively. In the present study we sought to determine if alpha-Syn could also modulate noradrenergic signaling, by studying its interactions with the norepinephrine transporter (NET). We co-transfected Ltk-cells with increasing amounts of alpha-Syn DNA and a constant amount of NET DNA, and observed a progressive decrease (68%) in [3H]-NE uptake in cells co-transfected with a ratio of 3:1 alpha-Syn:NET DNA. The Kd of transport did not change, but increasing alpha-Syn caused a decrease in the Vmax of the transporter, from 2.27+/-0.14 to 0.89+/-0.15 pmol/min/10(5) cells, with NET expression alone or 4:1 ratio of alpha-Syn:NET transfection, respectively. Decreases in surface biotinylation and [3H]-nisoxetine binding kinetics in intact cells revealed that NET cell surface expression was attenuated in correlation to the amount of alpha-Syn co-transfected into cells. The interaction between NET and alpha-Syn occurred via the NAC domain of alpha-Syn, the region directly responsible for self-aggregation. These findings are the first to show that alpha-Syn has a central role in the homeostasis of noradrenergic neurons. Together with our previous studies on dopamine and serotonin transporters, we propose that a primary physiological role of alpha-Syn may be to regulate the homeostasis of monoamines in synapses, through modulatory interactions of the protein with monoaminergic transporters."xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2006.05181.x"xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/author | "Sidhu A."xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/author | "Wersinger C."xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/author | "Jeannotte A."xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/pages | "3141-3152"xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/title | "Attenuation of the norepinephrine transporter activity and trafficking via interactions with alpha-synuclein."xsd:string |
| http://purl.uniprot.org/citations/17156375 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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