| http://purl.uniprot.org/citations/17157346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17157346 | http://www.w3.org/2000/01/rdf-schema#comment | "RNase L helps mediate the antiviral state induced by type I interferons (IFNalphabeta). Although herpes simplex virus (HSV) encodes inhibitors of the IFNalphabeta-induced antiviral response, the IFNalphabeta system serves the body as a first line of defense against HSV. We investigated whether RNase L limits HSV-2 replication and virulence. RNaseL(-/-) and wild-type C57BL/6 mice were infected intravaginally with HSV-2 strain 333. Although initial replication in the genital epithelium was similar, mice lacking RNase L developed less severe genital and neurologic disease than wild-type mice, survived longer, and contained lower viral titers in the nervous system. CD4(+) T cell infiltration into the genital tract and spinal cord of RNase L(-/-) mice was reduced, suggesting that a restricted inflammatory response may account for reduction in disease. Thus, RNase L does not play a significant role in control of HSV-2 infection in vivo; instead, RNase L may regulate aspects of the inflammatory response that contribute to disease."xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2006.10.042"xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/author | "Morrison L.A."xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/author | "Duerst R.J."xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/pages | "322-328"xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/title | "Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L."xsd:string |
| http://purl.uniprot.org/citations/17157346 | http://purl.uniprot.org/core/volume | "360"xsd:string |
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