| http://purl.uniprot.org/citations/17157356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17157356 | http://www.w3.org/2000/01/rdf-schema#comment | "The lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) forms as a consequence of oxidative stress, and acts as a signaling molecule or, at superphysiological levels, as a toxicant. The steady-state concentration of the compound reflects the balance between its generation and its metabolism, primarily through glutathione conjugation. Using an RNAi-based screen, we identified in Caenorhabditis elegans five glutathione transferases (GSTs) capable of catalyzing 4-HNE conjugation. RNAi knock-down of these GSTs (products of the gst-5, gst-6, gst-8, gst-10, and gst-24 genes) sensitized the nematode to electrophilic stress elicited by exposure to 4-HNE. However, interference with the expression of only two of these genes (gst-5 and gst-10) significantly shortened the life span of the organism. RNAi knock-down of the other GSTs resulted in at least as much 4-HNE adducts, suggesting tissue specificity of effects on longevity. Our results are consistent with the oxidative stress theory of organismal aging, broadened by considering electrophilic stress as a contributing factor. According to this extended hypothesis, peroxidation of lipids leads to the formation of 4-HNE in a chain reaction which amplifies the original damage. 4-HNE then acts as an "aging effector" via the formation of 4-HNE-protein adducts, and a resulting change in protein function."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mad.2006.11.025"xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Singh S.P."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Zimniak L."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Dandapat A."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Zimniak P."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Ayyadevara S."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Shmookler Reis R.J."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/author | "Siegel E.R."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/pages | "196-205"xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/title | "Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal."xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/17157356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17157356 |
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| http://purl.uniprot.org/uniprot/#_P91254-mappedCitation-17157356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17157356 |