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| http://purl.uniprot.org/citations/17158062 | http://www.w3.org/2000/01/rdf-schema#comment | "Appropriate neurogenesis and patterning of the forebrain requires the transcription factor Pax6, yet it is largely unknown how Pax6 exerts its effects at the molecular level. To characterize Pax6-mediated regulation of gene expression during murine forebrain neurogenesis, we performed microarray analysis with tissue from the dorsal Pax6-dependent telencephalon and the ventral Pax6-negative telencephalon at the onset of neurogenesis (E12) and at mid-neurogenesis (E15) in wild-type and Pax6-deficient mutant littermates. In the Pax6-deficient cortex the expression levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced. Regulation by Pax6 could be confirmed upon electroporation of a Pax6- and a dominant-negative Pax6-containing vector into embryonic cortex. Taken together, our data reveal novel insights into the molecular pathways regulated by Pax6 during cortical neurogenesis. Most intriguingly, this analysis revealed time- and region-specific differences in Pax6-mediated transcription, explaining the specific function of Pax6 at early and later stages of neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2006.10.008"xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Sigvardsson M."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Mader M.T."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Gotz M."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Wizenmann A."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Holm P.C."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/author | "Haubst N."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/pages | "99-119"xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/title | "Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon."xsd:string |
| http://purl.uniprot.org/citations/17158062 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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