| http://purl.uniprot.org/citations/1715889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1715889 | http://www.w3.org/2000/01/rdf-schema#comment | "Adhesion of B cell precursors to accessory cells in the bone marrow microenvironment may be required for normal early B cell development. Human bone marrow B cell precursors adhere more avidly than mature B cells to bone marrow-derived fibroblasts. To determine the mechanism of this adhesion, expression of adhesion proteins on human B precursor cells and cell lines was measured by flow cytometry. The very late antigen (VLA) integrins VLA-4 and VLA-5 were the only adhesion proteins expressed at higher levels in B cell precursors than mature B cells. Antibodies to the alpha and beta chains of VLA-4, but not VLA-5, significantly blocked binding to bone marrow-derived fibroblasts of immature B cells and cell lines. Although fibronectin is a ligand for VLA-4, anti-fibronectin antibody and a soluble fibronectin fragment containing the VLA-4 binding domain did not block adhesion, suggesting that VLA-4 is involved in adhesion of B cell precursors, but not as a fibronectin receptor. Vascular cell adhesion molecule-1 (VCAM-1), the other known counterreceptor for VLA-4, was identified on bone marrow-derived fibroblasts, and anti-VCAM-1 significantly blocked adhesion of normal B cell precursors to bone marrow-derived fibroblasts, indicating that VLA-4/VCAM-1 interactions are important in adhesion of B cell precursors to the bone marrow microenvironment."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci115403"xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/author | "Abboud C.N."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/author | "Nuccie B.L."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/author | "Ryan D.H."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/author | "Winslow J.M."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/pages | "995-1004"xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/title | "Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells."xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1715889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1715889 |
| http://purl.uniprot.org/citations/1715889 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1715889 |
| http://purl.uniprot.org/uniprot/P13612#attribution-79F6DC268CEFA2006D257EDE4CD96DDA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |
| http://purl.uniprot.org/uniprot/P13612#attribution-81A8983B84285820C5C9A290072509F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |
| http://purl.uniprot.org/uniprot/P05556#attribution-79F6DC268CEFA2006D257EDE4CD96DDA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |
| http://purl.uniprot.org/uniprot/P05556#attribution-81A8983B84285820C5C9A290072509F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |
| http://purl.uniprot.org/uniprot/P19320#attribution-79F6DC268CEFA2006D257EDE4CD96DDA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |
| http://purl.uniprot.org/uniprot/P19320#attribution-81A8983B84285820C5C9A290072509F2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1715889 |