| http://purl.uniprot.org/citations/17160016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17160016 | http://www.w3.org/2000/01/rdf-schema#comment | "Transformation of hematopoietic cells by the BCR/ABL oncogene is caused by perturbation of signal transduction pathways leading to altered patterns of gene expression and activity. By oligonucleotide microarray hybridization of polysomal RNA of untreated and STI571-treated 32D-BCR/ABL cells, we identified the beta-chemokine CCL9 as a gene regulated by BCR/ABL in a tyrosine kinase-dependent manner. BCR/ABL repressed CCL9 expression at the transcriptional level by mechanisms involving suppression of p38 MAP kinase, and modulation of the activity of CDP/cut and C/EBPalpha, two transcription regulators of myeloid differentiation. However, repression of C/EBP-dependent transcription did not prevent the induction of CCL9 expression by STI571, suggesting that C/EBPalpha is involved in maintaining rather than in inducing CCL9 expression. Restoration of CCL9 expression in 32D-BCR/ABL cells had no effect on the in vitro proliferation of these cells, but reduced their leukemogenic potential in vivo, possibly by recruitment of CD3-positive immune cells. Together, these findings suggest that downregulation of chemokine expression may be involved in BCR/ABL-dependent leukemogenesis by altering the relationship between transformed cells and the microenvironment."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1210146"xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Martinez R."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Blasi F."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Calabretta B."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Bardini M."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Iotti G."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Corradini F."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Lidonnici M.R."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Ferrari-Amorotti G."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Ronchetti M."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/author | "Rosafio C."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/pages | "3482-3491"xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/title | "Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells."xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17160016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17160016 |
| http://purl.uniprot.org/citations/17160016 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17160016 |
| http://purl.uniprot.org/uniprot/#_A2RRK7-mappedCitation-17160016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17160016 |
| http://purl.uniprot.org/uniprot/#_B2RQ57-mappedCitation-17160016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17160016 |
| http://purl.uniprot.org/uniprot/#_B7ZMZ2-mappedCitation-17160016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17160016 |
| http://purl.uniprot.org/uniprot/#_F8VQH0-mappedCitation-17160016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17160016 |