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| http://purl.uniprot.org/citations/17161026 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the transcriptional regulation of the human mitochondrial translation initiation factor 2 (IF2mt) gene. The minimal promoter region for the human IF2mt gene contains binding sites for Nuclear Respiratory Factor 2 (NRF-2), which is often involved in the transcription of mitochondrial-related genes. Electrophoresis mobility shift assay (EMSA) analyses indicated that NRF-2alpha/beta binds to the IF2mt promoter. Reporter assays, where HEK293T cells were co-transfected with an NRF-2alpha/beta-expressing vector and/or an IF2mt promoter reporter vector, revealed that NRF-2 trans-activates the IF2mt promoter. NRF-2 sites were also found in the promoters of several other mitochondrial translation factors, which suggests NRF-2 may play a key role in the regulation of mitochondrial protein synthesis."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mito.2006.10.005"xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/author | "Takeuchi N."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/author | "Hayashi R."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/author | "Farwell M.A."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/name | "Mitochondrion"xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/pages | "195-203"xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/title | "Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene."xsd:string |
| http://purl.uniprot.org/citations/17161026 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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