Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/17164313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17164313http://www.w3.org/2000/01/rdf-schema#comment"

Context

Administration of retinol-binding protein 4 (RBP-4) impairs insulin sensitivity in animals, and elevated serum concentrations have been associated with insulin resistance in humans.

Objective

We have studied whether weight loss influences RBP-4.

Patients and methods

Fasting serum concentrations of RBP-4 were measured before and 6 months after gastric banding surgery in 33 morbidly obese patients aged 40 +/-11 yr with a body mass index (BMI) of 46 +/-5 kg/m(2). Fourteen healthy subjects aged 29 +/-5 yr with a BMI less than 25 kg/m(2) served as controls. To characterize the association of weight loss with central and peripheral appetite regulation, the signaling protein agouti-related protein (AGRP), the orexigenic hormone ghrelin, and its recently identified antagonist obestatin were determined.

Results

At baseline, RBP-4 levels were markedly higher in obese than in lean subjects (2.7 +/- 0.5 vs. 0.9 +/-0.5 microg/ml; P < 0.001). In contrast, AGRP and obestatin were lower in obese subjects compared with lean controls (all P < 0.001). Six months after gastric banding, BMI was reduced to 40 +/- 5 kg/m(2), RBP-4 was reduced to 2.0 +/-0.7 microg/ml, AGRP increased from 1.8 +/- 1.1 to 3.4 +/-1.1 ng/ml, ghrelin increased from 93 +/- 58 to 131 +/-70 pg/ml, and obestatin increased from 131 +/- 52 to 173 +/-35 pg/ml (all P < 0.05). Individual changes of RBP-4 were associated with changes of BMI (r = 0.72), the homeostasis model assessment insulin resistance-index (r = 0.53), and total cholesterol (r = 0.42, for all P < 0.05).

Conclusion

Reductions in circulating RBP-4 may contribute to improved insulin resistance in morbidly obese subjects after weight loss. This is accompanied by favorable changes in appetite-regulating hormones, which might support the sustained weight loss after obesity surgery."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.org/dc/terms/identifier"doi:10.1210/jc.2006-1839"xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Prager G."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Schindler K."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Luger A."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Wolzt M."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Bohdjalian A."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Haider D.G."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/author"Ludvik B."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/pages"1168-1171"xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/title"Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects."xsd:string
http://purl.uniprot.org/citations/17164313http://purl.uniprot.org/core/volume"92"xsd:string
http://purl.uniprot.org/citations/17164313http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17164313
http://purl.uniprot.org/citations/17164313http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17164313
http://purl.uniprot.org/uniprot/#_P02753-mappedCitation-17164313http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17164313
http://purl.uniprot.org/uniprot/#_Q5VY30-mappedCitation-17164313http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17164313
http://purl.uniprot.org/uniprot/Q5VY30http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17164313
http://purl.uniprot.org/uniprot/P02753http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17164313