| http://purl.uniprot.org/citations/17167417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17167417 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinases (CDKs) drive major cell cycle events including the initiation of chromosomal DNA replication. We identified two S phase CDK (S-CDK) phosphorylation sites in the budding yeast Sld3 protein that, together, are essential for DNA replication. Here we show that, when phosphorylated, these sites bind to the amino-terminal BRCT repeats of Dpb11. An Sld3-Dpb11 fusion construct bypasses the requirement for both Sld3 phosphorylation and the N-terminal BRCT repeats of Dpb11. Co-expression of this fusion with a phospho-mimicking mutant in a second essential CDK substrate, Sld2, promotes DNA replication in the absence of S-CDK. Therefore, Sld2 and Sld3 are the minimal set of S-CDK targets required for DNA replication. DNA replication in cells lacking G1 phase CDK (G1-CDK) required expression of the Cdc7 kinase regulatory subunit, Dbf4, as well as Sld2 and Sld3 bypass. Our results help to explain how G1- and S-CDKs promote DNA replication in yeast."xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature05432"xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/author | "Diffley J.F."xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/author | "Zegerman P."xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/pages | "281-285"xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/title | "Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/17167417 | http://purl.uniprot.org/core/volume | "445"xsd:string |
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