| http://purl.uniprot.org/citations/17170753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17170753 | http://www.w3.org/2000/01/rdf-schema#comment | "Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To gain more insight into the physiological functions of Elongin A, we generated Elongin A-deficient mice. Elongin A homozygous mutant (Elongin A(-/-)) embryos demonstrated a severely retarded development and died at between days 10.5 and 12.5 of gestation, most likely due to extensive apoptosis. Moreover, mouse embryonic fibroblasts (MEFs) derived from Elongin A(-/-) embryos exhibited not only increased apoptosis but also senescence-like growth defects accompanied by the activation of p38 MAPK and p53. Knockdown of Elongin A in MEFs by RNA interference also dramatically induced the senescent phenotype. A study using inhibitors of p38 MAPK and p53 and the generation of Elongin A-deficient mice with p53-null background suggests that both the p38 MAPK and p53 pathways are responsible for the induction of senescence-like phenotypes, whereas additional signaling pathways appear to be involved in the mediation of apoptosis in Elongin A(-/-) cells. Taken together, our results suggest that Elongin A is required for the transcription of genes essential for early embryonic development and downregulation of its activity is tightly associated with cellular senescence."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4402067"xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Nakabeppu Y."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Miyata K."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Ohnishi Y."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Sakumi K."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Yamazaki K."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Yasukawa T."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Kitajima S."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Ohtsuki Y."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Tamamori-Adachi M."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Aso T."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/author | "Onishi S."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/pages | "716-726"xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/title | "Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A."xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/17170753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17170753 |
| http://purl.uniprot.org/citations/17170753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17170753 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-17170753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17170753 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-17170753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17170753 |