| http://purl.uniprot.org/citations/17173864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17173864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17173864 | http://www.w3.org/2000/01/rdf-schema#comment | "Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.11.122"xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.11.122"xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Mowers J.C."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Mowers J.C."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Ramaswamy S."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Ramaswamy S."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "McDonald C."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "McDonald C."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Coussens N.P."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/author | "Coussens N.P."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/pages | "1-5"xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/pages | "1-5"xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/title | "Crystal structure of the Nod1 caspase activation and recruitment domain."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/title | "Crystal structure of the Nod1 caspase activation and recruitment domain."xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/volume | "353"xsd:string |
| http://purl.uniprot.org/citations/17173864 | http://purl.uniprot.org/core/volume | "353"xsd:string |