| http://purl.uniprot.org/citations/17173927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17173927 | http://www.w3.org/2000/01/rdf-schema#comment | "Although quantitative identification and viable enrichment of natural regulatory T cells (T-regs) in humans are problematic, such steps would greatly facilitate the analysis of these cells in disease states. In an attempt to identify markers that are sensitive and specific for human T-regs, we analyzed the expression of fourteen intracellular and cell surface markers on human CD4(+) cells. Many markers were partially selective for CD25(hi) T-regs, but consistent and specific discrimination of functional T-regs was only made possible by focus on CD127, the alpha chain of the IL-7 receptor. Although most CD4(+) human T cells express CD127, T-regs exhibiting suppressive activity in vitro display distinctly lower surface expression of this marker, irrespective of their level of CD25 expression. Sorted cells with the surface phenotype CD4(+)CD25(+)CD127(low) had higher levels of intracellular FOXP3 and CTLA-4 and, as determined by functional assays, were suppressive, hypoproliferative, and poorly responsive to TCR signaling. The CD4(+)CD25(+)CD127(low) phenotype was also found to be characteristic of T-regs found in mice and in rhesus macaques. This surface phenotype should allow for quantitative studies of regulatory T cells in disease states as well as for enrichment of live regulatory T cells for functional analyses and/or expansion in vitro."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jim.2006.10.008"xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/author | "McCune J.M."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/author | "Poon C."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/author | "Sinclair E."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/author | "Hartigan-O'Connor D.J."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/name | "J Immunol Methods"xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/pages | "41-52"xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/title | "Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells."xsd:string |
| http://purl.uniprot.org/citations/17173927 | http://purl.uniprot.org/core/volume | "319"xsd:string |
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