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| http://purl.uniprot.org/citations/17174955 | http://www.w3.org/2000/01/rdf-schema#comment | "A structural hallmark of lysosomes is heterogeneity of their contents. We describe a method for isolation of particulate materials from human placental lysosomes. After a methionine methyl ester-induced disruption of lysosomes and two density gradient centrifugations we obtained a homogeneous membrane fraction and another one enriched in particulate inclusions. The latter exhibited a yellow-brown coloration and contained bodies lacking a delimiting membrane, which were characterised by a granular pattern and high electron density. The lipofuscin-like inclusion materials were rich in tripeptidyl peptidase I, beta-glucuronidase, acid ceramidase and apolipoprotein D and contained proteins originating from diverse subcellular localisations. Here we show that human term placenta contains lipofuscin-like lysosomal inclusions, a phenomenon usually associated with senescence in postmitotic cells. These findings imply that a simple pelleting of a lysosomal lysate is not appropriate for the isolation of lysosomal membranes, as the inclusions tend to be sedimented with the membranes."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.12.005"xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/author | "Schmidt B."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/author | "Hasilik A."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/author | "Schroder B."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/author | "Elsasser H.P."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/pages | "102-108"xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/title | "Characterisation of lipofuscin-like lysosomal inclusion bodies from human placenta."xsd:string |
| http://purl.uniprot.org/citations/17174955 | http://purl.uniprot.org/core/volume | "581"xsd:string |
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