| http://purl.uniprot.org/citations/17178402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17178402 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase-3beta (GSK-3beta) is thought to mediate morphological responses to a variety of extracellular signals. Surprisingly, we found no gross morphological deficits in nervous system development in GSK-3beta null mice. We therefore designed an shRNA that targeted both GSK-3 isoforms. Strong knockdown of both GSK-3alpha and beta markedly reduced axon growth in dissociated cultures and slice preparations. We then assessed the role of different GSK-3 substrates in regulating axon morphology. Elimination of activity toward primed substrates only using the GSK-3 R96A mutant was associated with a defect in axon polarity (axon branching) compared to an overall reduction in axon growth induced by a kinase-dead mutant. Consistent with this finding, moderate reduction of GSK-3 activity by pharmacological inhibitors induced axon branching and was associated primarily with effects on primed substrates. Our results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all GSK-3 substrates is associated with a specific morphological outcome."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.10.031"xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Yoshimura T."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Wang Y.M."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Kim W.Y."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Yokota Y."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Anton E.S."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Snider W.D."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/author | "Zhou F.Q."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/pages | "981-996"xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/title | "Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth."xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/17178402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17178402 |
| http://purl.uniprot.org/citations/17178402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17178402 |
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| http://purl.uniprot.org/uniprot/#_E9QAQ5-mappedCitation-17178402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178402 |
| http://purl.uniprot.org/uniprot/#_Q64FM2-mappedCitation-17178402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178402 |
| http://purl.uniprot.org/uniprot/#_Q2NL51-mappedCitation-17178402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178402 |