| http://purl.uniprot.org/citations/17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17178714 | http://www.w3.org/2000/01/rdf-schema#comment | "The cystic fibrosis transmembrane conductance regulator (CFTR) is recognized as a multifunctional protein that is involved in Cl(-) secretion, as well as acting as a regulatory protein. In order for acid secretion to take place a complex interaction of transport proteins and channels must occur at the apical pole of the parietal cell. Included in this process is at least one K(+) and Cl(-) channel, allowing for both recycling of K(+) for the H,K-ATPase, and Cl(-) secretion, necessary for the generation of concentrated HCl in the gastric gland lumen. We have previously shown that an ATP-sensitive potassium channel (K(ATP)) is expressed in parietal cells. In the present study we measured secretagogue-induced acid secretion from wild-type and DeltaF508-deficient mice in isolated gastric glands and whole stomach preparations. Secretagogue-induced acid secretion in wild-type mouse gastric glands could be significantly reduced with either glibenclamide or the specific inhibitor CFTR-inh172. In DeltaF508-deficient mice, however, histamine-induced acid secretion was significantly less than in wild-type mice. Furthermore, immunofluorescent localization of sulfonylurea 1 and 2 failed to show expression of a sulfonylurea receptor in the parietal cell, thus further implicating CFTR as the ATP-binding cassette transporter associated with the K(ATP) channels. These results demonstrate a regulatory role for the CFTR protein in normal gastric acid secretion."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608427200"xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Egan M.E."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Ferreira E."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Caputo C."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Bell R.L."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Geibel J.P."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Roberts K.E."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Kirchhoff P."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Sidani S.M."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Socrates T."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/author | "Stelter L."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/pages | "6068-6074"xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/title | "DeltaF508 mutation results in impaired gastric acid secretion."xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17178714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17178714 |
| http://purl.uniprot.org/citations/17178714 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17178714 |
| http://purl.uniprot.org/uniprot/#_F6U9G7-mappedCitation-17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178714 |
| http://purl.uniprot.org/uniprot/#_E9PVD7-mappedCitation-17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178714 |
| http://purl.uniprot.org/uniprot/#_P26361-mappedCitation-17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178714 |
| http://purl.uniprot.org/uniprot/#_P70163-mappedCitation-17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178714 |
| http://purl.uniprot.org/uniprot/#_P70164-mappedCitation-17178714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17178714 |