| http://purl.uniprot.org/citations/17178715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17178715 | http://www.w3.org/2000/01/rdf-schema#comment | "Na/Ca exchanger activity is important for calcium extrusion from the cardiomyocyte cytosol during repolarization. Animal models exhibiting altered Na/Ca exchanger expression display abnormal cardiac phenotypes. In humans, elevated Na/Ca exchanger expression/activity is linked with pathophysiological conditions including arrhythmia and heart failure. Whereas the molecular mechanisms underlying Na/Ca exchanger biophysical properties are widely studied and generally well characterized, the cellular pathways and molecular partners underlying the specialized membrane localization of Na/Ca exchanger in cardiac tissue are essentially unknown. In this report, we present the first direct evidence for a protein pathway required for Na/Ca exchanger localization and stability in primary cardiomyocytes. We define the minimal structural requirements on ankyrin-B for direct Na/Ca exchanger interactions. Moreover, using ankyrin-B mutants that lack Na/Ca exchanger binding activity, and primary cardiomyocytes with reduced ankyrin-B expression, we demonstrate that direct interaction with the membrane adaptor ankyrin-B is required for the localization and post-translational stability of Na/Ca exchanger 1 in neonatal mouse cardiomyocytes. These results raise exciting new questions regarding potentially dynamic roles for ankyrin proteins in the biogenesis and maintenance of specialized membrane domains in excitable cells."xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m607096200"xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/author | "Bhasin N."xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/author | "Mohler P.J."xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/author | "Cunha S.R."xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/pages | "4875-4883"xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/title | "Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B."xsd:string |
| http://purl.uniprot.org/citations/17178715 | http://purl.uniprot.org/core/volume | "282"xsd:string |
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