| http://purl.uniprot.org/citations/17178890 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17178890 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemoprevention or treatment of cancer. Nevertheless, the mechanisms underlying these antineoplastic effects remain poorly understood. Here, we report that induction of the cancer-specific proapoptotic cytokine melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24) by several NSAIDs is an essential step for induction of apoptosis and G(2)-M growth arrest in cancer cells in vitro and inhibition of tumor growth in vivo. We also show that MDA-7/IL-24-dependent up-regulation of growth arrest and DNA damage inducible 45 alpha (GADD45alpha) and GADD45gamma gene expression is sufficient for cancer cell apoptosis via c-Jun NH(2)-terminal kinase (JNK) activation and growth arrest induction through inhibition of Cdc2-cyclin B checkpoint kinase. Knockdown of GADD45alpha and GADD45gamma transcription by small interfering RNA abrogates apoptosis and growth arrest induction by the NSAID treatment, blocks JNK activation, and restores Cdc2-cyclin B kinase activity. Our results establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-2068"xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Libermann T.A."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Correa R.G."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Zerbini L.F."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Silver M."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Joseph M."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Ruchusatsawat K."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Czibere A."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Zhou J.R."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Otu H."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/author | "Takayasu Y."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/pages | "11922-11931"xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/title | "A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/17178890 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17178890 |
| http://purl.uniprot.org/citations/17178890 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17178890 |