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http://purl.uniprot.org/citations/17180083http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17180083http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17180083http://www.w3.org/2000/01/rdf-schema#comment"A systematic search for genes differentially expressed in human tissues resulted in the isolation of a gene encoding a protein with high homology to DNase I. In addition to the recently described cDNA sequence (Parrish et al., 1995) we have isolated a transcript, alternatively spliced in the 5' noncoding region. The gene is located between the QM and the XAP-2 gene in Xq28 and encodes a 302 amino acid protein with 39% identity to human DNase I. Besides a high homology at the nucleotide and amino acid level, most exon-intron boundaries of DNase I and DNase X are identical, indicating that both genes may have evolved from a common ancestor. The predicted function was verified by expression of a recombinant protein in an inducible bacterial system and detection of DNase activity. In contrast to DNase I a 18 kdal amino terminal fragment of the full length 35 kdal protein exhibited DNase activity."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Delius H."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Delius H."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Poustka A."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Poustka A."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Zentgraf H."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Zentgraf H."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Coy J.F."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Coy J.F."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Himmele R."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Himmele R."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Velhagen I."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/author"Velhagen I."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/name"Cell Death Differ."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/name"Cell Death Differ."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/pages"199-206"xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/pages"199-206"xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/title"Isolation, differential splicing and protein expression of a DNase on the human X chromosome."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/title"Isolation, differential splicing and protein expression of a DNase on the human X chromosome."xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/volume"3"xsd:string
http://purl.uniprot.org/citations/17180083http://purl.uniprot.org/core/volume"3"xsd:string