| http://purl.uniprot.org/citations/17182001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17182001 | http://www.w3.org/2000/01/rdf-schema#comment | "Hedgehog signaling plays important roles in embryonic patterning of multicellular organisms. This pathway is ultimately transmitted by the zinc-finger transcriptional factor Gli, of which activity is suppressed by Sufu, a negative regulator of this signaling. To clarify this regulation to more detail, we screened for Sufu-binding proteins. We identified GSK3beta as a specific binding partner of Sufu by mass spectrometric analysis. GSK3beta bound to Sufu both in vitro and in vivo. Down-regulation of GSK3beta expression by RNAi in Hedgehog-responsive cells attenuated Hedgehog signaling, suggesting that GSK3beta functions as a positive regulator of Hedgehog signaling. In addition, an in vitro kinase assay showed that GSK3beta phosphorylates Sufu and phosphorylation-mimicking mutant of Sufu showed significantly decreased ability to bind Gli1 and could not suppress the Gli-mediated expression of a reporter gene efficiently. These results strongly suggest that GSK3beta phosphorylates Sufu to positively regulate Hedgehog signaling in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.12.058"xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/author | "Takenaka K."xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/author | "Kise Y."xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/pages | "501-508"xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/title | "GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/17182001 | http://purl.uniprot.org/core/volume | "353"xsd:string |
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