| http://purl.uniprot.org/citations/17182038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17182038 | http://www.w3.org/2000/01/rdf-schema#comment | "Paternally expressed 1 (Peg1)/mesoderm specific transcript (Mest) is an imprinted gene, which is only transcribed from the paternal (father's) allele. In some human cancer tissues, an alternatively spliced variant of PEG1/MEST mRNA using a different promoter of a distinct first exon is expressed from both paternal and maternal alleles. We previously reported that Peg1/Mest expression was markedly up-regulated in obese adipose tissue in mice. Moreover, transgenic overexpression of Peg1/Mest in the adipose tissue resulted in the enlargement of adipocytes in size. Given the potential pathophysiologic relevance in obesity, we examined the nature of increased expression of Peg1/Mest in obese adipose tissue. In obese adipose tissue, expression of Peg1/Mest was increased, but not that of other imprinted genes tested. The transcription rate of Peg1/Mest was increased in obese adipose tissue. We found at least four isoforms of mouse Peg1/Mest generated by use of the alternative first exons. We also demonstrated that the abundantly expressed Peg1/Mest in obese adipose tissue retained monoallelic expression. This is the first report of monoallelic induction of Peg1/Mest in adult tissues."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.12.002"xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Miura S."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Kohda T."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Ogawa Y."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Yasuda K."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Ezaki O."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Suganami T."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Kamei Y."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/author | "Ishino F."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/pages | "91-96"xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/title | "Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner."xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://purl.uniprot.org/core/volume | "581"xsd:string |
| http://purl.uniprot.org/citations/17182038 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17182038 |
| http://purl.uniprot.org/citations/17182038 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17182038 |
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