| http://purl.uniprot.org/citations/17182560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17182560 | http://www.w3.org/2000/01/rdf-schema#comment | "NK cells express both inhibitory and activatory receptors that allow them to recognize target cells through HLA class I Ag expression. KIR3DL1 is a receptor that recognizes the HLA-Bw4 public epitope of HLA-B alleles. We demonstrate that polymorphism within the KIR3DL1 receptor has functional consequences in terms of NK cell recognition of target. Inhibitory alleles of KIR3DL1 differ in their ability to recognize HLA-Bw4 ligand, and a consistent hierarchy of ligand reactivity can be defined. KIR3DS1, which segregates as an allele of KIR3DL1, has a short cytoplasmic tail characteristic of activatory receptors. Because it is very similar to KIR3DL1 in the extracellular domains, it has been assumed that KIR3DS1 will recognize a HLA-Bw4 ligand. In this study, we demonstrate that KIR3DS1 is expressed as a protein at the cell surface of NK cells, where it is recognized by the Z27 Ab. Using this Ab, we found that KIR3DS1 is expressed on a higher percentage of NK cells in KIR3DS1 homozygous compared with heterozygous donors. In contrast to the inhibitory KIR3DL1 allotypes, KIR3DS1 did not recognize HLA-Bw4 on EBV-transformed cell lines."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.1.235"xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "Parham P."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "Middleton D."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "O'Connor G.M."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "Gardiner C.M."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "Cunningham R.T."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/author | "Guinan K.J."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/pages | "235-241"xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/title | "Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells."xsd:string |
| http://purl.uniprot.org/citations/17182560 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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