| http://purl.uniprot.org/citations/17182902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17182902 | http://www.w3.org/2000/01/rdf-schema#comment | "Cip1-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication in vitro and is required for mammalian cells to enter S phase. Here, we show that a significant proportion of Ciz1 is retained in nuclear foci following extraction with nuclease and high salt. This suggests that Ciz1 is normally immobilized by interaction with non-chromatin nuclear structures, consistent with the nuclear matrix. Furthermore, matrix-associated Ciz1 foci strikingly colocalize with sites of newly synthesized DNA in S phase nuclei, suggesting that Ciz1 is present in DNA replication factories. Analysis of green fluorescent protein-tagged fragments indicates that nuclear immobilization of Ciz1 is mediated by sequences in its C-terminal third, encoded within amino acids 708-830. Immobilization occurs in a cell-cycle-dependent manner, most probably during late G1 or early S phase, to coincide with its reported point of action. Although C-terminal domains are sufficient for immobilization, N-terminal domains are also required to specify focal organization. Combined with previous work, which showed that the DNA replication activity of Ciz1 is encoded by N-terminal sequences, we suggest that Ciz1 is composed of two functionally distinct domains: an N-terminal replication domain and a C-terminal nuclear matrix anchor. This could contribute to the formation or function of DNA replication factories in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03327"xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Rahman F.A."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Gerlach B."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Ainscough J.F."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Sedo A."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Coverley D."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/author | "Sercombe H."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/pages | "115-124"xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/title | "C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix."xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17182902 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17182902 |
| http://purl.uniprot.org/citations/17182902 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17182902 |
| http://purl.uniprot.org/uniprot/F6XWQ4#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/F7AT58#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/F7BM53#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/F6S5B6#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/A0A0A0MQJ7#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/F7D5G9#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/A0A0A6YVQ0#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/Q3TXU6#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |
| http://purl.uniprot.org/uniprot/A2AN61#attribution-4137FA240320B16C0B69C81AA59C234A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17182902 |