| http://purl.uniprot.org/citations/17184966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17184966 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipoxin A(4) (LXA(4)) is an eicosanoid which is produced via lipoxygenases and characteristic of its anti-inflammatory effect in many metabolites of arachidonic acid, which are mostly pro-inflammatory. Glucocorticoids are well known also for their strong anti-inflammatory action but induce 5-lipoxygenase, essential to synthesize leukotrienes, which are pro-inflammatory. To elucidate the interaction of glucocorticoids and lipoxin A(4) for anti-inflammation, we analyzed in vitro expression of lipoxin A(4) receptor (ALX) on human neutrophils and the in vivo anti-inflammatory effect of glucocorticoids and LXA(4) using a dermal inflammation mouse model. ALX mRNA was up-regulated by dexamethasone (Dex) in human neutrophils. A glucocorticoid receptor antagonist, mifepristone, suppressed up-regulation of ALX induced by Dex. LXA(4) and/or Dex decreased CD11b expression on human neutrophils and suppressed mouse dermatitis induced by LTB(4). These results suggest that anti-inflammatory effects of glucocorticoids depend at least partly on up-regulation of ALX and that the lipoxin system could be a negative feedback regulator for LTB(4)."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2006.06.023"xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/author | "Endo H."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/author | "Hashimoto A."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/author | "Hayashi I."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/author | "Kitasato H."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/pages | "81-85"xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/title | "Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation."xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/17184966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17184966 |
| http://purl.uniprot.org/citations/17184966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17184966 |
| http://purl.uniprot.org/uniprot/#_P25090-mappedCitation-17184966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17184966 |
| http://purl.uniprot.org/uniprot/P25090 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17184966 |