| http://purl.uniprot.org/citations/17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17185321 | http://www.w3.org/2000/01/rdf-schema#comment | "The initiation and maintenance of G1 cell cycle arrest is a key feature of animal development. In the Drosophila ectoderm, G1 arrest first appears during the seventeenth embryonic cell cycle. The initiation of G1(17) arrest requires the developmentally-induced expression of Dacapo, a p27-like Cyclin E-Cdk2 inhibitor. The maintenance of G1(17) arrest requires Rbf1-dependent repression of E2f1-regulated replication factor genes, which are expressed continuously during cycles 1-16 when S phase immediately follows mitosis. The mechanisms that trigger Rbf1 repressor function and mediate G1(17) maintenance are unknown. Here we show that the initial downregulation of expression of the E2f1-target gene RnrS, which occurs during cycles 15 and 16 prior to entry into G1(17), does not require Rbf1 or p27(Dap). This suggests a mechanism for Rbf1-independent control of E2f1 during early development. We show that E2f1 protein is destroyed in a cell cycle-dependent manner during S phase of cycles 15 and 16. E2f1 is destroyed during early S phase, and requires ongoing DNA replication. E2f1 protein reaccumulates in epidermal cells arrested in G1(17), and in these cells the induction of p27(Dap) activates Rbf1 to repress E2f1-target genes to maintain a stable G1 arrest."xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02738"xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/author | "Duronio R.J."xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/author | "Shibutani S."xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/author | "Swanhart L.M."xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/pages | "467-478"xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/title | "Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/17185321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17185321 |
| http://purl.uniprot.org/citations/17185321 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17185321 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ0-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI54-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHG1-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGM3-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_O18402-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_Q24472-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_Q7JVY2-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_Q7KPZ3-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_M9NDQ2-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_P02299-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |
| http://purl.uniprot.org/uniprot/#_P48592-mappedCitation-17185321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185321 |