| http://purl.uniprot.org/citations/17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17185997 | http://www.w3.org/2000/01/rdf-schema#comment | "The cardiac sodium channel (SCN5A) is a target for the treatment of arrhythmias. We hypothesized that vulnerability to atrial fibrillation (AF) could be caused by genetic variation in SCN5A. We recruited 157 patients with early-onset AF who lacked traditional risk factors, and 314 matched controls. SCN5A was subject to targeted genotyping of a common loss-of-function H558R polymorphism and comprehensive mutation scanning. Genotype frequencies in the AF cohort vs controls were as follows: HH, 50 vs 63%; HR, 40 vs 33%; and RR, 10 vs 4% (P=0.008). Additional coding sequence mutations were ruled out. The R558 allele was more common in patients than in controls (30 vs 21%, P=0.002), conferring an odds ratios for AF of 1.6 (95% confidence interval 1.2-2.2). The SCN5A R558 allele, present in one-third of the population, thus constitutes a risk factor for lone AF and may increase susceptibility to sodium channel blocker-induced proarrhythmia."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.clpt.6100016"xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/author | "Ballew J.D."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/author | "Olson T.M."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/author | "Herron K.J."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/author | "Rodeheffer R.J."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/author | "Chen L.Y."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/name | "Clin Pharmacol Ther"xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/pages | "35-41"xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/title | "A common polymorphism in SCN5A is associated with lone atrial fibrillation."xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17185997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17185997 |
| http://purl.uniprot.org/citations/17185997 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17185997 |
| http://purl.uniprot.org/uniprot/#_D3YHE8-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
| http://purl.uniprot.org/uniprot/#_E9PHB6-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
| http://purl.uniprot.org/uniprot/#_A3EY18-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
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| http://purl.uniprot.org/uniprot/#_A3EY21-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M6R3-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
| http://purl.uniprot.org/uniprot/#_A0A7R6M6R4-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |
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| http://purl.uniprot.org/uniprot/#_E9PG18-mappedCitation-17185997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17185997 |