| http://purl.uniprot.org/citations/17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17187060 | http://www.w3.org/2000/01/rdf-schema#comment | "The retinoblastoma protein (pRB) negatively regulates the progression from G1 to S phase of the cell cycle, in part, by repressing E2F-dependent transcription. pRB also possesses E2F-independent functions that contribute to cell-cycle control--for example, during pRB-mediated cell-cycle arrest pRB associates with Skp2, the F-box protein of the Skp1-Cullin-F-box protein (SCF) E3 ubiquitin ligase complex, and promotes the stability of the cyclin-dependent kinase-inhibitor p27(Kip1) through an unknown mechanism. Degradation of p27(Kip1) is mediated by ubiquitin-dependent targeting of p27(Kip1) by SCF -Skp2 (ref. 4). Here, we report a novel interaction between pRB and the anaphase-promoting complex/cyclosome (APC/C) that controls p27(Kip1) stability by targeting Skp2 for ubiquitin-mediated degradation. Cdh1, an activator of APC/C, not only interacts with pRB but is also required for a pRB-induced cell-cycle arrest. The results reveal an unexpected physical convergence between the pRB tumour-suppressor protein and E3 ligase complexes, and raise the possibility that pRB may direct APC/C to additional targets during pRB-mediated cell-cycle exit."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1532"xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Dick F.A."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Rape M."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Dyson N.J."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Binne U.K."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Kaelin W.G. Jr."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Naar A.M."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/author | "Classon M.K."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/pages | "225-232"xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/title | "Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit."xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/17187060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17187060 |
| http://purl.uniprot.org/citations/17187060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17187060 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_P06400-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |
| http://purl.uniprot.org/uniprot/#_P51965-mappedCitation-17187060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17187060 |