| http://purl.uniprot.org/citations/1718822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1718822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1718822 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated two novel serpin-encoding sequences from EB22, a chondrocytic cell line derived from a mouse teratocarcinoma. Both sequences fall within the Spi-2 sub-family, and are related to the gene encoding human alpha 1-antichymotrypsin (ACT), a major acute-phase reactant. Considerable amplification of the Spi-2 gene family in the mouse has occurred, hindering the identification of a functional equivalent of the human gene. However, one of the sequences described here, EB22/4, exhibits several features which indicate that it may represent the physiological rodent equivalent of ACT. The sequence is expressed in the liver, as expected, and is induced several-fold during the acute-phase response. The P1 amino acid residue, which is primarily responsible for inhibitor specificity, is Met rather than the human Leu, most probably a functionally conservative substitution. Analysis of the orthologous sequence in related rodents demonstrates conservation of the predicted reactive centre-encoded specificity. The second isolated cDNA, EB22/3, encodes an unexpected Cys residue at the P1 position in the reactive centre, and represents a novel sub-class of the Spi-2 serine proteinase inhibitor (serpin)-encoding gene family. At least one of the sequences appears to be expressed at sites of skeletal deposition during the later stages of mouse foetal development, indicating a role for serpins during development."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(91)90201-l"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(91)90201-l"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(91)90201-L"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Hill R.E."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Hill R.E."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Inglis J.D."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Inglis J.D."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Davidson D.R."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/author | "Davidson D.R."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/pages | "213-220"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/pages | "213-220"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/title | "Isolation of two cDNAs encoding novel alpha-1-antichymotrypsin-like proteins in a murine chondrocytic cell line."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/title | "Isolation of two cDNAs encoding novel alpha-1-antichymotrypsin-like proteins in a murine chondrocytic cell line."xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/1718822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1718822 |