| http://purl.uniprot.org/citations/17189204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17189204 | http://www.w3.org/2000/01/rdf-schema#comment | "The active thyroid hormone, triiodothyronine (T3), regulates mitochondrial uncoupling protein activity and related thermogenesis in peripheral tissues. Type 2 deiodinase (DII), an enzyme that catalyzes active thyroid hormone production, and mitochondrial uncoupling protein 2 (UCP2) are also present in the hypothalamic arcuate nucleus, where their interaction and physiological significance have not been explored. Here, we report that DII-producing glial cells are in direct apposition to neurons coexpressing neuropeptide Y (NPY), agouti-related protein (AgRP), and UCP2. Fasting increased DII activity and local thyroid hormone production in the arcuate nucleus in parallel with increased GDP-regulated UCP2-dependent mitochondrial uncoupling. Fasting-induced T3-mediated UCP2 activation resulted in mitochondrial proliferation in NPY/AgRP neurons, an event that was critical for increased excitability of these orexigenic neurons and consequent rebound feeding following food deprivation. These results reveal a physiological role for a thyroid-hormone-regulated mitochondrial uncoupling in hypothalamic neuronal networks."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2006.12.002"xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Richard D."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Friedman J.M."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Ricquier D."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Liu Z.W."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Horvath T.L."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Diano S."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Gao X.B."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Coppola A."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Andrews Z.B."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Roy M.C."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/author | "Paradis E."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/pages | "21-33"xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/title | "A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2."xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/17189204 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17189204 |
| http://purl.uniprot.org/citations/17189204 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17189204 |
| http://purl.uniprot.org/uniprot/#_A0A140LHA5-mappedCitation-17189204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17189204 |
| http://purl.uniprot.org/uniprot/#_D3YXM5-mappedCitation-17189204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17189204 |
| http://purl.uniprot.org/uniprot/#_A0A8Z1S5Q0-mappedCitation-17189204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17189204 |
| http://purl.uniprot.org/uniprot/#_P70406-mappedCitation-17189204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17189204 |