| http://purl.uniprot.org/citations/17189474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17189474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17189474 | http://www.w3.org/2000/01/rdf-schema#comment | "Rcd-1, a protein highly conserved across eukaryotes, was initially identified as a factor essential for nitrogen starvation-invoked differentiation in fission yeast, and its Saccharomyces cerevisiae homolog, CAF40, has been identified as part of the CCR4-NOT transcription complex, where it interacts with the NOT1 protein. Mammalian homologs are involved in various cellular differentiation processes including retinoic acid-induced differentiation and hematopoetic cell development. Here, we present the 2.2 A X-ray structure of the highly conserved region of human Rcd-1 and investigate possible functional abilities of this and the full-length protein. The monomer is made up of six armadillo repeats forming a solvent-accessible, positively-charged cleft 21-22 A wide that, in contrast to other armadillo proteins, stays fully exposed in the dimer. Prompted by this finding, we established that Rcd-1 can bind to single- and double-stranded oligonucleotides in vitro with the affinity of G/C/T >> A. Mutation of an arginine residue within the cleft strongly reduced or abolished oligonucleotide binding. Rcd-1's ability to bind to nucleic acids, in addition to the previously reported protein-protein interaction with NOT1, suggests a new feature in Rcd-1's role in regulation of overall cellular differentiation processes."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.062600507"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.062600507"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Pai E.F."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Pai E.F."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Gillon W."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Gillon W."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Garces R.G."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/author | "Garces R.G."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/name | "Protein Sci."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/pages | "176-188"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/pages | "176-188"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/title | "Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/title | "Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties."xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/17189474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17189474 |
| http://purl.uniprot.org/citations/17189474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17189474 |
| http://purl.uniprot.org/citations/17189474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17189474 |
| http://purl.uniprot.org/citations/17189474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17189474 |