| http://purl.uniprot.org/citations/17190793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17190793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17190793 | http://www.w3.org/2000/01/rdf-schema#comment | "Central synapses exhibit spontaneous neurotransmitter release that is selectively regulated by cAMP-dependent protein kinase A (PKA). We now show that synaptic vesicles contain synaptotagmin-12, a synaptotagmin isoform that differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. We demonstrate that synaptotagmin-12 is phosphorylated by cAMP-dependent PKA on serine(97), and show that expression of synaptotagmin-12 in neurons increases spontaneous neurotransmitter release by approximately threefold, but has no effect on evoked release. Replacing serine(97) by alanine abolishes synaptotagmin-12 phosphorylation and blocks its effect on spontaneous release. Our data suggest that spontaneous synaptic-vesicle exocytosis is selectively modulated by a Ca(2+)-independent synaptotagmin isoform, synaptotagmin-12, which is controlled by cAMP-dependent phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200607021"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200607021"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Maximov A."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Maximov A."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Shin O.H."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/author | "Shin O.H."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/pages | "113-124"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/pages | "113-124"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/title | "Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/title | "Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/17190793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17190793 |