Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/17191017http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17191017http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17191017http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17191017http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Hepatitis B virus (HBV) genotypes B and C are predominant in Japan. Previously, we reported that approximately 9% of HBV carriers in the Ehime area of western Japan were infected with genotype D (HBV/D) and their sequences closely related. Recently, serum samples from 3 patients with chronic HBV/D infections living in Tokyo and the surrounding area became available for testing. The purpose of this study was to determine whether the HBV/D isolates from these different areas of Japan are closely related.

Methods

Of the 3 Tokyo area patients infected with HBV/D, 2 had chronic hepatitis, and 1 had hemophilia with a history of frequent coagulation factor injections. The complete HBV/D genome sequences of each were determined, and compared with those of subjects from the Ehime area.

Results

All 3 HBV/D sequences had a genomic length of 3,182 bases, and the hepatitis B surface antigen subtype was ayw3. Phylogenetic analysis revealed that the 1 of the HBV/D isolates was closely related to the isolates from Ehime Prefecture, while 1 was similar and 1 was clearly distinct.

Conclusion

Our results indicate that HBV/D infections in Japan are heterogeneous."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.org/dc/terms/identifier"doi:10.1159/000098241"xsd:string
http://purl.uniprot.org/citations/17191017http://purl.org/dc/terms/identifier"doi:10.1159/000098241"xsd:string
http://purl.uniprot.org/citations/17191017http://purl.org/dc/terms/identifier"doi:10.1159/000098241"xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Fujisawa T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Fujisawa T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Fujisawa T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Matsuura K."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Matsuura K."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Matsuura K."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Harada H."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Harada H."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Harada H."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Shibayama T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Shibayama T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Shibayama T."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Hiasa Y."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Hiasa Y."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Hiasa Y."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Michitaka K."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Michitaka K."xsd:string
http://purl.uniprot.org/citations/17191017http://purl.uniprot.org/core/author"Michitaka K."xsd:string
▶