| http://purl.uniprot.org/citations/17192003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17192003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17192003 | http://www.w3.org/2000/01/rdf-schema#comment | "The three-dimensional (3D) NMR solution structure (MeOH) of the highly hydrophobic delta-conotoxin delta-Am2766 from the molluscivorous snail Conus amadis has been determined. Fifteen converged structures were obtained on the basis of 262 distance constraints, 25 torsion-angle constraints, and ten constraints based on disulfide linkages and H-bonds. The root-mean-square deviations (rmsd) about the averaged coordinates of the backbone (N, C(alpha), C) and (all) heavy atoms were 0.62+/-0.20 and 1.12+/-0.23 A, respectively. The structures determined are of good stereochemical quality, as evidenced by the high percentage (100%) of backbone dihedral angles that occupy favorable and additionally allowed regions of the Ramachandran map. The structure of delta-Am2766 consists of a triple-stranded antiparallel beta-sheet, and of four turns. The three disulfides form the classical 'inhibitory cysteine knot' motif. So far, only one tertiary structure of a delta-conotoxin has been reported; thus, the tertiary structure of delta-Am2766 is the second such example. Another Conus peptide, Am2735 from C. amadis, has also been purified and sequenced. Am2735 shares 96% sequence identity with delta-Am2766. Unlike delta-Am2766, Am2735 does not inhibit the fast inactivation of Na+ currents in rat brain Na(v)1.2 Na+ channels at concentrations up to 200 nM."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbdv.200590035"xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbdv.200590035"xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sarma S.P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sarma S.P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Balaram P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Balaram P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sikdar S.K."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sikdar S.K."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Krishnan K.S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Krishnan K.S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Ramasamy P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Ramasamy P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sudarslal S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Sudarslal S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Iengar P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Iengar P."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Kumar G.S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/author | "Kumar G.S."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/name | "Chem. Biodivers."xsd:string |
| http://purl.uniprot.org/citations/17192003 | http://purl.uniprot.org/core/name | "Chem. Biodivers."xsd:string |