| http://purl.uniprot.org/citations/17194709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17194709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17194709 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to regulating cell motility, contractility, and cytokinesis, the actin cytoskeleton plays a critical role in the regulation of transcription and gene expression. We have previously identified a novel muscle-specific actin-binding protein, STARS (striated muscle activator of Rho signaling), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription. To further dissect the STARS/SRF pathway, we performed a yeast two-hybrid screen of a skeletal muscle cDNA library using STARS as bait, and we identified two novel members of the ABLIM protein family, ABLIM-2 and -3, as STARS-interacting proteins. ABLIM-1, which is expressed in retina, brain, and muscle tissue, has been postulated to function as a tumor suppressor. ABLIM-2 and -3 display distinct tissue-specific expression patterns with the highest expression levels in muscle and neuronal tissue. Moreover, these novel ABLIM proteins strongly bind F-actin, are localized to actin stress fibers, and synergistically enhance STARS-dependent activation of SRF. Conversely, knockdown of endogenous ABLIM expression utilizing small interfering RNA significantly blunted SRF-dependent transcription in C2C12 skeletal muscle cells. These findings suggest that the members of the novel ABLIM protein family may serve as a scaffold for signaling modules of the actin cytoskeleton and thereby modulate transcription."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m607549200"xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m607549200"xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M607549200"xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Barrientos T."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Barrientos T."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Bezprozvannaya S."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Bezprozvannaya S."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Frank D."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Frank D."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Frey N."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Frey N."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Kuwahara K."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Kuwahara K."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Pipes G.C.T."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Pipes G.C.T."xsd:string |
| http://purl.uniprot.org/citations/17194709 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |