| http://purl.uniprot.org/citations/17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17196307 | http://www.w3.org/2000/01/rdf-schema#comment | "The hyperphosphorylation of tau protein is one of the hallmarks of Alzheimer's disease (AD) and of the associated cognitive decline. EMK1 (MARK2) is a serine/threonine kinase which phosphorylates tau and MAP2. An involvement of this kinase in memory functions is not established. We used a behavioral approach to study the phenotype of EMK1-null mice (EMK1-KO) as a possible model of MAP2/tau altered phophorylation. Compared to wild type mice, EMK1-KO mice did not differ in non-cognitive aspects of behavior, such as locomotion in activity cages, or anxiety in the elevated plus maze. However, they exhibited lower performance in the first stage of acquisition of a hippocampal-dependent spatial learning, as assessed in a radial water maze, although, they acquired the task with repeated training. They were again found to be impaired on re-learning a new platform position. In addition, they exhibited poor long-term retention performance. These data underline the importance on both early memory processes and long-term retrieval, of the dynamic instability of microtubules generated by the phosphorylation of MAPs."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2006.10.014"xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/author | "Buhot M.C."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/author | "Darmon M."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/author | "Segu L."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/author | "Costet P."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/author | "Pascaud A."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/pages | "231-240"xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/title | "Impairment of spatial learning and memory in ELKL Motif Kinase1 (EMK1/MARK2) knockout mice."xsd:string |
| http://purl.uniprot.org/citations/17196307 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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| http://purl.uniprot.org/citations/17196307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17196307 |
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| http://purl.uniprot.org/uniprot/#_E9Q9N6-mappedCitation-17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196307 |
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| http://purl.uniprot.org/uniprot/#_F7CVZ7-mappedCitation-17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196307 |
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| http://purl.uniprot.org/uniprot/#_E9Q2J6-mappedCitation-17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196307 |
| http://purl.uniprot.org/uniprot/#_E9Q8H5-mappedCitation-17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196307 |
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| http://purl.uniprot.org/uniprot/#_F6UY70-mappedCitation-17196307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196307 |