| http://purl.uniprot.org/citations/17196522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17196522 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective of this study was to determine in a rat model of hepatocellular carcinoma (HCC) the effects of the antiangiogenic agent TNP-470 on cell proliferation and effectors of the apoptotic pathway, including p53, p21WAF1/CIP1, cyclin D, and cyclin E. Tumor was induced in male Wistar rats by diethylnitrosamine and promoted by two-thirds hepatectomy plus acetaminofluorene administration. Experiments were carried out at 28 weeks after initiating the treatment. TNP-470 was administered at 30 mg/kg, 3 times per week from 20 to 28 weeks. Serum levels of vascular endothelial growth factor (VEGF) and hepatocyte growth factor beta (HGFbeta) liver expression were increased by hepatocarcinogenesis (+38% and +183%, respectively), and treatment with TNP-470 was able to prevent the increase in these angiogenic factors induced by HCC. HCC coursed with reduced expression of p21WAF1/CIP1 and p53 (-63% and -60%, respectively). Hepatic expression of cyclin D and cyclin E were significantly increased in rats with HCC (+108% and +115%, respectively). In animals with experimental carcinogenesis, a significant increase in the expression of Cdk4 and CdK2 was also observed (+119% and +187%, respectively). These effects were prevented by TNP-470 administration. In conclusion, cell-cycle inhibition by TNP-470 is mediated at least in part by an activation of p21WAF1/CIP1 because of a p53-dependent mechanism, with reduction of the cyclin D-Cdk4 and cyclin E-Cdk 2 expression. These cytostatic effects should be considered when assessing the efficacy of TNP-470 for anti-angiogenic therapy. These findings may prove useful for the development of therapies for the treatment of human HCC."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.trsl.2006.07.004"xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Gonzalez P."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Culebras J.M."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Gonzalez-Gallego J."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Duran M.C."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Mauriz J.L."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/author | "Molpeceres V."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/name | "Transl Res"xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/pages | "46-53"xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/title | "Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism."xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/17196522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17196522 |
| http://purl.uniprot.org/citations/17196522 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17196522 |
| http://purl.uniprot.org/uniprot/#_B1WC54-mappedCitation-17196522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196522 |
| http://purl.uniprot.org/uniprot/#_P39949-mappedCitation-17196522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17196522 |
| http://purl.uniprot.org/uniprot/B1WC54 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17196522 |
| http://purl.uniprot.org/uniprot/P39949 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17196522 |