| http://purl.uniprot.org/citations/17196820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/17196820 | http://www.w3.org/2000/01/rdf-schema#comment | "The double-stranded (ds) RNA-activated protein kinase, PKR, has a key role in the innate immunity response to viral infection in higher eukaryotes. PKR contains an N-terminal dsRNA-binding domain and a C-terminal kinase domain. In the prevalent autoinhibition model for PKR activation, dsRNA binding induces a conformational change that leads to the release of the dsRNA-binding domain from the kinase, thus relieving the inhibition of the latent enzyme. Structural and biophysical data now favor a model whereby dsRNA principally functions to induce dimerization of PKR via the kinase domain. This dimerization model has implications for other PKR regulatory mechanisms and represents a new structural paradigm for control of protein kinase activity."xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tibs.2006.12.003"xsd:string |
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| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/author | "Cole J.L."xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/author | "Cole J.L."xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/name | "Trends Biochem. Sci."xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/name | "Trends Biochem. Sci."xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/pages | "57-62"xsd:string |
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| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/title | "Activation of PKR: an open and shut case?"xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/title | "Activation of PKR: an open and shut case?"xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/17196820 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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