| http://purl.uniprot.org/citations/17197426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17197426 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory T cells play an essential role in preventing fetal rejection by the maternal immune system. Here we show that, based on the expression of CCR5, regulatory T cells can be divided into a highly suppressive CCR5+ and a far less suppressive CCR5-subpopulation, suggesting that the former represent the effector arm of regulatory T cells. Although regulatory T cells from CCR5-/-gene deletion mutants still suppress, they are less effective mediators of maternal-fetal tolerance. The accumulation of CCR5+ regulatory T cells at this site appears to be enhanced by alloantigen. This finding is in stark contrast to the systemic expansion of regulatory T cells during pregnancy, which appears to be alloantigen-independent. The fact that CCR5+ regulatory T cells preferentially accumulate in the gravid uterus and that expression of CCR5 on regulatory T cells can be induced by activation lead us to propose that CCR5 is responsible for the accumulation of those regulatory T cells that have been activated by paternal antigens."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0604268104"xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/author | "Betz A.G."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/author | "Andersen K.G."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/author | "Welch K.A."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/author | "Kallikourdis M."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/pages | "594-599"xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/title | "Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus."xsd:string |
| http://purl.uniprot.org/citations/17197426 | http://purl.uniprot.org/core/volume | "104"xsd:string |
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