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http://purl.uniprot.org/citations/17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17197814http://www.w3.org/2000/01/rdf-schema#comment"

Background

Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission.

Objective

To investigate if the presence of HLA-B alleles with the Bw4 epitope in HIV-1-infected men decreased the risk of transmission to their female sex partners.

Methods

The study comprised 304 HIV-1-infected men with hemophilia and 325 female sex partners. HLA class I genes were amplified using sequence-specific primers. Products of the polymerase chain reaction were blotted on nylon membranes and hybridized with sequence-specific oligonucleotide probes. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI) for HIV-1 infection among the women.

Results

Among the 325 women, 44 (13.5%) were infected with HIV-1. HIV-1 infection in the women was associated with the HLA-B genotype of their male partner [Bw6/Bw6, 22/118 (18.6%); Bw4/Bw6, 18/154 (11.7%); Bw4/Bw4, 4/53 (7.6%)]. Compared with men who were homozygous for Bw6, men who carried Bw4 were about half as likely to have transmitted HIV-1 to their female partner (OR, 0.52; 95% CI, 0.27-0.98; P = 0.04). Transmission was higher among couples in which the man's ethnicity was other than White (OR, 2.60; 95% CI, 1.25-5.40; P = 0.01), but the association between HIV-1 transmission and HLA-B genotype was not confounded by race.

Conclusion

The presence of HLA-Bw4 in HIV-1-infected men was associated with a decreased risk of male-to-female HIV-1 transmission, which suggests that these alleles reduce infectivity for HIV-1."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.org/dc/terms/identifier"doi:10.1097/qad.0b013e3280123840"xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Carrington M."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Gao X."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Martin M.P."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"O'Brien S.J."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"O'Brien T.R."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Goedert J.J."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Pfeiffer R.M."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/author"Welzel T.M."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/name"AIDS"xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/pages"225-229"xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/title"HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples."xsd:string
http://purl.uniprot.org/citations/17197814http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/17197814http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17197814
http://purl.uniprot.org/citations/17197814http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17197814
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
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http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-17197814http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17197814
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