| http://purl.uniprot.org/citations/17197920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17197920 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonrandom cytogenetic abnormalities of chromosomes 6, 7, and 17 have been reported within low-grade endometrial stromal sarcomas (LGESSs), and among these abnormalities, the t(7;17)(p15;q21) is the most common aberration described. Previously we had shown that this translocation joins 2 genes, JAZF1 and JJAZ1, located on chromosomes 7 and 17, respectively. To determine the frequency of the t(7;17), we analyzed 4 stromal nodules and 24 LGESS by both reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization (FISH). In addition, we examined 4 cases of highly cellular leiomyoma, a benign morphologic mimic of LGESS. Overall, evidence for the JAZF1-JJAZ1 fusion was found in 60% of endometrial stromal neoplasms analyzed (8/16 ESS and 4/4 stromal nodules). One LGESS demonstrated only rearrangement of 7p15 by FISH analysis and karyotypic analysis of this case showed t(6;7)(p21;p15). The fusion was not detected in any highly cellular leiomyomas. Our data suggest that the JAZF1-JJAZ1 fusion is a frequent, although nonuniform, feature of endometrial stromal neoplasia, irrespective of benign versus malignant classification and smooth muscle differentiation. In addition, the detection of the fusion by reverse transcriptase-polymerase chain reaction or FISH for JJAZ1 at 7p15 may be diagnostically useful."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.pas.0000213327.86992.d1"xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/author | "Sklar J."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/author | "Dal Cin P."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/author | "Nucci M.R."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/author | "Koontz J."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/author | "Harburger D."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/name | "Am J Surg Pathol"xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/pages | "65-70"xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/title | "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms."xsd:string |
| http://purl.uniprot.org/citations/17197920 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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